PATHOLOGY OF AUTISM
WITH FOCUS ON THE
PATHOPHYSIOLOGY OF VACCINE-INDUCED AUTISM
a.k.a. GARDASIL SYNDROME
a.k.a. CERVARIX SYNDROME
a.k.a. VACCINE INDUCED AUTISM SYNDROME (VIAS)
a.k.a. VACCINE INDUCED GULF WAR SYNDROME (VIGWS)
Simplified Version v1.51a Copyright© February 18, 2013 - Working Copy; Publication Pending
PHILLIPS OFFIT WAKEFIELD Syndrome is a progressive inflammatory condition, initiated by trauma to the immune system (including a vaccine or medical procedure), that fails to self-limit, which results in varying degrees of cognitive and motor skill disorders, neuritis, cerebral vasculitis, and gut inflammation, which becomes self-sustaining in otherwise healthy children and adults, which may signal the activation and virulence of dormant pathogens and enteroviruses. A secondary cascade of inflammation may result when biofilms and persister cells are torn apart for their calcium, magnesium, and other molecules, in an effort to feed inflammation, which may liberate (dormant) pathogens that were imprisoned inside these structures by the immune system. Death may suddenly occur when a parasitic pathogen, such as Bartonella, has previously invaded the host, and the Amorphous Aluminum Hydroxyphosphate Sulfate adjuvant forces the immune system to aggressively come back on line, after the Bartonella has suppressed cytokine production through Toll-Like Receptor 4 (TLR4)(reference). A Cytokine Storm in the lungs and airways may ensue, driven by Interleukin-13, which may result in the fatal overproduction of mucus in lungs and airways(reference). Bartonella may be transmitted to humans through infected mosquitoes, fleas, ticks, mites, raw goat or cows milk, and much more. Inflammation may become self sustaining due to old and new allergens challenging a heightened immune system in which eosinophils and mast cells may become increasingly more sensitized and abundant, especially in the gut. The gut may then become inflamed which may result in IBS (gastroparesis if left untreated) and malabsorption, which may down-regulate many metabolic cycles and enzymes, such as H3K4 trimethylation, which can ultimately result in impaired SEMA5, which controls AXON growth, proliferation, and cone guidance, which may ultimately negatively affect the development of brain structures relating to cognitive and motor abilities, in addition to the direct affects of inflammation upon cells and structures of the brain, such as the myelin-producing oligodendrocytes. Oxidative stress and inflammation rapidly deplete Magnesium, Vitamin D (critical for apoptosis of infected cells), B12, and other nutrients, resulting in deficient enzyme production throughout the body, which together with an observed GSTM-1, GSTT-1, GSTP-1, or similar genetic Glutathione S-Transferase disorder, may mimic a defective AGA Gene on Chromosome 4, and ultimately result in conditions similar to Lysosomal Storage Disorder (LSD), which in severe cases, may further contribute to a system-wide failure of the brain and body due to plaque, and increase the risk of cancer if not arrested. Elevated histamine may typically be observed and is caused by mast cells and eosinophils, triggered by allergens from newly-formed allergies as the result of food proteins contacting immune cells in the lining of an inflamed gut, which then produce antibodies to that food. An unexpected discovery was the presence of vector-borne (biting insect) pathogens, such as Bartonella, Babesia, Borrelia burgdorferi, or FL1953, whose symptoms may also be present in other family membors. Symptoms of Chronic Lyme Disease was found in the majority of children with severe adverse effects, who received the Gardasil HPV Vaccine. Mononucleosis with exposure to a fungus, with or without a vaccination, All children in this cohort, who had Mononucleosis in their medical history, have had a severe reaction to the Gardasil HPV vaccine, and Mononucleosis has proven to be virtually a 100% predictor for these debiliating inflammatory events. Sustained cerebral vasculitis, which resulted in severe head pressure/migraines in these older children, may also be responsible for head-banging in younger children, has been shown to be aggravated by mold. This is commonly initiated by a vaccine protein(s) binding to the epithelial lining of blood vessels and other structures, including the cerebral vasculature and hippocampus, which was found in tissue samples from two deceased teenage girls following their Gardasil HPV vaccine. This documented cerebral vasculitis is also suspected in the brain and may result in Autism (cognitive disorders in infants and toddlers). Insomnia, nausea, fatigue, irritability, and head pressure (resulting in possible head banging in toddlers) are often the first signs, along with lightheadedness upon arising from a sitting position. In rare cases, sudden death (SIDS in infants) may result. A Glutathione S-Transferase deficiency was observed in a significant number of these children, along with elevated levels of aluminum, and some had indications of Pyroluria. Virtually all had indications of Postural Orthostatic Tachycardia Syndrome. Acute inflammatory events in children are most commonly triggered by a vaccination or other immune system trauma, including medical procedures, and except for LPS Stimulated Cytokine Testing, typically remains undetectable by common lab tests. Inflammation may actually increase in later stages, possibly due to IL-10 suppression by a Chron's Disease and gastroparesis-like condition. SANEVAX, a vaccine watchdog group, performed post mortem testing on tissue removed from various structures and vasculature of two deceased teenage girls with unremarkable medical histories, who died suddenly and unexpectedly after receiving the Gardasil HPV vaccine. The HPV16, L1 Protein Fragment was found attached to the endothelial lining of blood vessels in the brain, and also to other structures, including the hippocampus. Also noted was the L1 HPV 16 protein fragment was still bound to the amorphous aluminum hydroxyphosphate sulfate substrate/adjuvant, where it was causing inflammation, and causing immune cells to produce antibodies in that area of the brain, where no vaccine should go. We further hypothesize that the Polysorbate emulsifier may have aided passage of the vaccine through the blood brain barrier, since this has already been proven with other medications in the lab. We document the immune system dysregulation that we observed, which resulted in cascades of potentially life-threatening events, ranging from Autism and autoimmune disease, to death.
CONCLUSION: In a growing subset of the population, especially in those subgroups of the population exposed to vector-borne pathogens, vaccines have now been observed to trigger and actually participate in cerebral vasculitis, and other inflammatory disorders. These may become acute or life threatening in the presence of active infections which may have already evoked an inflammatory immune response, particularly those pathogens which inhibit the immune system, such as Bartonella, and/or those pathogens that cause blood viscosity to increase or coagulate, such as Babesia. Vector-borne pathogens have been detected or suspected in the majority of the children in this study, including the FL1953 protozoan, which was found together with Bartonella and Babesia in two teens who presented with seizures. If, however, an adolescent girl becomes pregnant (as observed in the Gardasil contingent), the high levels of Anti-Inflammatory Interleukin 10, released as the result of pregnancy, has been observed to down-regulate and arrest this inflammatory condition.
An immune response may result in inflammation which fails to self-limit, triggering a cascade of potentially debilitating or life-threatening events. The inflammation can be the direct result of a vaccine adjuvant, such as amorphous aluminum, or pathogens, especially vector-borne pathogens, especially if the patient had a prior exposure to a filamentous bacteria or fungus which activated the the TH17 Immune system, and the resulting inflammatory Interleukin 17. If the aluminum adjuvant compound is attached to its vaccine antigen, such as a protein or protein fragment, and is drawn to an unforeseen binding site in the body, and that binding site is located in a critical structure, such as the endothelial lining of blood vessels or the the hippocampus of the human brain, both inflammation and antibodies may be produced at these binding sites, and may result in vasculitis, encephalitis, cognitive disorders, seizures, stroke, Macrophage Activation Syndrome, or similar disorder. Intramuscular vaccines become even more dangerous in the absence of syringe aspiration, and during times when the blood brain barrier may be permeated, such as during periods when histamine is being released by the patient. This includes, but is not limited to patients suffering from colds, allergies, and teething. These events may become more prolonged or severe if a Glutathione S-Transferase Deficiency is present (genetic defect where the liver fails to properly clear toxins), especially in patients where blood vessels and capillaries are small or narrowed. The Sickle Cell trait and Pathogens such as Bartonella may contribute to a further narrowing of blood vessels and the release of VEGF, which may additionally narrow vessels, leading to reduced oxygen and blood flow to critical organs in the brain, such as the hippocampus, plus the proliferation of blood vessels that could potentially supply tumors. Together with a GST deficiency, toxins and waste products may accumulate and inflame the lining of these vessels and in the brain, leading to further inflammation and seizures, especially during times that vaccines force the TH2 immune system to produce antibodies. This does not appear to include CCSVI. This may also provide a link to brain lesions, stroke, MS, and Dementia. This chronic/systemic inflammation may trigger/activate glial cells, which may then result in the expression of SEMA3B/SEMA5A and/or related semaphorins/factors, which may then negatively affect the growth and guidance of developing axons, and may further prevent their re-growth after injury, resulting in what we presently call AUTISM.
Simplified Version, v1.471, a copyrighted work in progress.
Trauma to the immune system may trigger chronic systemic inflammation, which may then result in cascades of debilitating or life-threatening events. The following is a simplified abstract.
a.k.a. GARDASIL SYNDROME
a.k.a. CERVARIX SYNDROME
a.k.a. VACCINE INDUCED AUTISM SYNDROME (VIAS)
a.k.a. VACCINE INDUCED GULF WAR SYNDROME (VIGWS)
Simplified Version v1.471 Copyright© JUNE 24, 2012 - Working Copy; Publication Pending
The CDC is currently doing major damage control for disseminating information that there
was allegedly no link between vaccines and
autism, based on "research" submitted by Poul Thorsen. As a result of this
"research," the country of South Korea fully vaccinated its population with the
MMR vaccine. In 2011, the U.S. Department of Justice commenced
prosecution of Mr. Poul Thorsen
alleging that he fabricated the research that alleged that there was no link
between the MMR Vaccine and AUTISM, and stole the $1,000,000.00 grant money from the CDC, and used it to buy a house
and a Harley Motorcycle. Also in 2011, following the mass
MMR vaccination campaign in South Korea, 1 in 38 South Korean children
now are reported to have Autistic traits
link). In 2012, diagnostic guidelines are being re-written (DSM-5) to
exclude many (about 39%) of the children currently classified as autistic.
Thus, the CDC's answer to the autism epidemic is simply to juggle words and
statistics, and continue denying the cause.
During the past several years, Dr. Rudolph Tanzi, who specializes in Alzheimer's research at Massachusetts General Hospital, collaborated with other researchers in the field of autism. They performed genetic comparison testing of the blood from autistic children and control groups. They used DNA chips, which allows mass DNA profiling within hours. The result was that there was NO COMMON GENETIC LINK that could be found among the majority of the autistic group. Similarities were found in only 10% of the blood samples from the autistic children. The mutations that were found appeared on chromosome 16, and also on chromosome 5, which is adjacent to the SEMA5 gene. SEMA5A is related to AXON growth. This suggests that Autism is mostly an ACQUIRED syndrome. Unfortunately, there is also evidence that suggests SEMA5 may inhibit the re-growth of damaged axons (reference) in the brain.
SHORTENED ABSRTACT (references removed): Cognitive and motor impairment can result from inflammation initiated by a vaccine or its adjuvant. If inflammation becomes sustained, pathogens, including dormant pathogens, may become virulent. Sustained gut inflation, typically due to T-Reg cell dysfunction, or vaccine antigens attaching to unforeseen binding sites, may result in new allergies from food proteins contacting exposed immune cells in the wall of an inflamed gut. This gut inflammation remains chronic as long as the child continues to ingest these foods or is exposed to allergens. Stress also elevates kryptopyrroles, which deplete zinc and vitamin B6 (pyridoxine), which results in elevated copper, which may result in cascades of debilitating events, including failure to clear excessive intracellular Ca+, which can result in acute and prolonged head pressure, which may result in head-banging in young children in an attempt to stop pain. The inflammation-induced stress also inhibits H3 and H4 methylation, which inhibits H3K4me3 (H3K4 trimethylation). SEMA5 relies on H3K4me3, and controls the growth, guidance, and proliferation of AXONS in the brain, but under stress, can repel axon growth and inhibit the re-growth of injured axons. Another product of H3 methylation is H3K9acK14ac, and along with H3K4me3, affects the growth and proliferation of T-Cells, which can result in an innate immune system favorable to ear infections and the proliferation of pathogens. If left unchecked, sensitization of eosinophils and mast cells may result in additional food and chemical sensitivities, and this can result in excessive histamine, which may result in a permeated blood brain barrier and/or POTS (Postural Orthostatic Tachycardia Syndrome), due to histamine-dilated blood vessels. Inhibited methylation also impairs cortisol production, which may result in Addison Disease-like symptoms, including fatigue, photophobia (light sensitivity), and hypersensitivity to sound. When glial cells in the brain become inflamed, neighboring myelin-producing oligodendrocytes may become involved, which may ultimately result in longer cognitive processing times, and myelin-related motor disorders, and longer latency during nerve-conduction testing (the electrical signal in a nerve, takes longer to travel through the nerve). Lloyd W. Phillips, Copyright 2012 as a Work in Progress, contact: PPL@Mailbox7.net
ABSTRACT: Cognitive impairment, as seen in ASD, may result from inflammation, especially uncontrolled, self-sustained, or chronic, which may signal pathogens such as viruses, spirochetes, and enteroviruses (including those that are dormant), to become virulent. This condition may become enhanced by nutritional deficiencies, especially by malabsorption due gut inflammation, and the result of this inflammation and oxidative stress may be elevated kryptopyrroles, which deplete zinc and Vit B6, and may result in additional cascades of uncontrolled gut, brain, and other organ inflammation, all of which may be initiated by aluminum hydroxide or similar pro-inflammatory vaccine adjuvant (reference), which may subsequently evoke the release of Interleukin 1b, IL18, and/or other pro-inflammatory cytokines, in addition to binding to, and causing apoptosis of motor neurons in the spinal chord (reference1) (reference2) (reference3) (reference4) (reference5) (reference6) (reference7) (reference8) (reference9). We observed poorly controlled inflammation, which then resulted in chronic and systemic inflammation that failed to self-limit in a significant number of children, especially those who had a history of EBV. Mononucleosis (Glandular Fever) proved to be a predictor of a severe adverse reaction to the Gardasil HPV vaccine and other vaccines. We also observed that those who took in large amounts of milk from dairy products were at higher risk, due to calcium inhibiting the absorption of magnesium, which is used in the making of about 300 human enzymes. Many children were found to posses a common GSTM-1 polymorphism, plus a history of exposure to mold and/or fungus prior to vaccination, which may have activated the TH17 immune system prior to vaccination. Upon testing for vector-borne pathogens in a small subset, many of these children were found to be positive for Bartonella (many presenting with a history of splenomegaly and typical stripe rash), Babesia, Borrelia burgdorferi, and FL1953. Indications of a TH2i (reference) failure was present in a significant number of these children, and was evidenced by newly acquired chronic food and chemical sensitivities, which could generally be mediated by the administration of oral Low Dose Naltrexone in the older group of children, who suffered severe adverse effects from the Gardasil HPV vaccine (Phillips et al, 2010). The acute, debilitating, migraine-like head pressure described by the older children, may be the cause of head-banging in infants and young children, and may be the result of the body's failure to properly mobilize intracellular CA+ (reference), during TH2i inhibition. This was determined by the positive outcome when a Ca+ mobilizer was administered orally. Stress-mediated dysregulation may result in neuronal apoptosis in the hippocampus (reference), suggesting a link to Sensory Processing Disorder (reference), and possibly Dyspraxia (reference). (It is acknowledged that cognitive impairments may also result from toxins, including metals, insecticides, and pathogens, such as Streptococcus-associated PANDAS, but that is not the focus of our investigation.) Viral Interference may occur when multiple pathogens are present, making a diagnosis of any single pathogen very difficult. A third possibility is a combination of the two, but either may result in dysregulated methylation. Genes that regulate chromatin structure and function, such as MECP2 and other methyl-CpG-binding proteins, the histone deacetylase HDAC4, the histone H3 lysine 9 (H3K9)–specific methyltransferase EHMT1/KMT1D/GLP, and the H3K4 demethylase JARID1C/KDM5C/SMCX (reference), are now prime suspects. Likewise for CDH10 T2, at Chromosome 5, which is associated with the development of neuronal cell adhesion molecules. In particular, H3K4me3 appears to be particularly important for neuronal health because neuronal differentiation is dependent on H3K4 trimethylation, which is mediated by the mixed-lineage leukemia (MLL) methyltransferase and transcriptional activation of RE-1 silencing transcription factor (REST) sensitive genes. (reference1) (reference2) In addition, hippocampal learning and memory require MLL1 -mediated H3K4 trimethylation at growth and plasticity-regulating genes. (reference1) (reference2), which may be further affected by elevated cortisol, resulting from chronic inflammation. Elevated cortisol has been found to inhibit development of neurons in the hippocampus. Elevated histamine, from overly sensitized or overly active eosinophils and /or mast cells (reference), may also disrupt critical balances involved in H3K4 trimethylation. Both H3K4me3 and H3K9acK14ac are associated with active genes necessary for human T-Cell development in the innate immune system. Over 3,330 gene promoters were unexpectedly found to be associated with the histone phase of these semaphorins (reference), which exemplifies the requirement for a healthy gut and balanced meals to supply the nutritional needs for these complex and critical processes, because imbalances, such as elevated Cu+ will inhibit methylation of H3 histone, resulting in hypoexpression of both H3K4me3 and H3K9acK14ac, which may ultimately inhibit the development of both axons and T-Cells (reference). Elevated serum Cu+ (Pyroluria) was observed among the study group, some of which tested positive for chronic Lyme Disease or co-infections. High Cu+ was also found in autistic children in the Children's Institute Of Pittsburg Study. Pyroluria results in a metabolite called kryptopyrrole. Kryptopyrrole binds to a number of necessary human nutrients, including zinc, pyridoxine (vit B6), etc., and depletes them. Excessive kryptopyrrole production can also be due to a genetic polymorphism, or triggered by stress OR A VACCINE REACION. If excessive or uncontrolled inflammation and/or oxidative stress results, typically due to signaling dormant pathogens to become virulent, cascades of debilitating metabolic events may result, including autism in younger children, and Alzheimer’s in older adults. If this series of events occurs in a pregnant female, it can adversely affect the fetus, well before birth. Newcastle Disease also causes high CU+ and a suppressed innate immune system, and is usually found in chickens, but can be transmitted to humans under rare circumstances. The name, SEMA3B, is used interchangeably with SEMA5 in conjunction with cone guidance in the developing axon or neuron, but SEMA3B is the term typically used when describing the ability of this semaphorin to REPEL growth, and PREVENT AXON GROWTH AFTER INJURY (reference), and also inhibit angiogenesis in tumors (SEMA3F) (reference).
SUMMATION: Current intramuscular vaccines and their adjuvants may produce an inflammatory response which fails to self-limit, triggering elevated levels of cortisol, histamine, and kryptopyrroles which deplete zinc and vit B6), resulting in a cascade of potentially debilitating or life-threatening events through H3 H4 methylation inhibition, which also effects AXON and T-Cell development and growth. Inflammation becomes self-sustaining by sensitizing eosinophils and mast cells, which feed inflammation upon contact by an ever increasing number of allergens. Chronic /systemic inflammation may eventually trigger /activate glial cells, which may inhibit the expression of SEMA3B/SEMA5A and /or related semaphorins via H3 and H4 methylation, which may negatively impact the growth and guidance of developing axons, and may further prevent their re-growth after injury, resulting in what we presently call AUTISM. If glial cell inflammation is allowed to continue over a long period of time, neighboring myelin-producing oligodendrocytes may be negatively impacted, resulting myelin-related degenerative diseases. Autism rates are now increasing almost exponentially in proportion to vaccinations. Copyright© 2012 by Lloyd W. Phillips, as a work in progress.
EXPANDED & SIMPLIFIED VERSION: Trauma to the immune system can cause inflammation, an immune response. Under certain conditions, the resulting inflammation may fail to self-limit, and cascades of debilitating and/or life-threatening events may follow (Phillips et al, 2010).
Inflammation is typically initiated by one or more of the following four events: 1) Vaccination(s) (PMID: 18382856), especially concomitant or closely spaced, such as the Gardasil HPV vaccine; 2) Accidental or deliberate trauma to the body, including concussion and whiplash, which is more dangerous in females; 3) Invasive surgical procedures; and 4) Acute or sustained exposure to, or ingestion of (pathogens) mold, fungus, pesticides, or other environmental toxin(s). The risks posed by toxins increases according to the time spent in an air-conditioned environment, due to the retention of toxins that would normally be expelled from the body by sweat, a natural detoxifier.
The cause of excessive or uncontrolled inflammation is typically due to one or more of three risk factors: 1) genetic defects or variants, including common genetic variants, called polymorphisms. A polymorphism is a genetic defect that is found in one or more percent of the population. A Glutathione S-Transferase Deficiency, such as a GSTM1 genetic defect, has been found in 59.6% of the population. This common genetic defect causes the liver to be less efficient at filtering out toxins and metals from the blood, including not only mercury, but the aluminum hydroxide found in vaccines, anti-perspirants, baking powder, and antacids, 2) body burden, such as active infections, or latent or dormant pathogens such as spirochetes, protozoa, parasites, bacteria, and viruses, especially the arthritis-associated Epstein Barr Virus, and 3) pathogen-hijacked cytokines, which can change the way genes act. An example is Acne Vulgaris, which inhibits Interleukin-10, an anti-inflammatory cytokine (hormone), and prevents it from effectively stopping inflammation throughout the body. The cytokine is actually "genetically hijacked," and turned into "viral interleukin 10."
Vaccines pose a special risk factor for initiating an uncontrolled and unpredictable inflammatory response, because, except for POWDERMED™, they are designed for a hypothetically perfect immune system, require injection into a muscle (intramuscular use), and therefore include an "adjuvant" (foreign chemical) to make the body think it is under attack by causing inflammation, hypothetically limited only to the injection site. Under perfect conditions, the inflammation caused by the typical Aluminum Hydroxide adjuvant in modern vaccines may initiate an inflammatory response, then is bound to GLUTATHIONE, malic acid derivatives, etc., and is ultimately removed through the liver and kidneys. Unfortunately, not all humans have perfect immune systems, or receive proper nutrition. In addition, that same ALUMINUM HYDROXIDE is used to create allergies and asthma in lab animals (ref). A person with an allergy or an infant that is teething, may releases excessive HISTAMINE, released primarily by sensitive eosinophils and mast cells. Histamine dilates blood vessels, including the Blood Brain Barrier, and small amounts of the inflammation-causing Aluminum adjuvant from a vaccine may wander into the brain, Central Nervous System, or other unwanted place.
As an example, in the documented case of an 11 yr old Canadian girl, vaccinated with the Gardasil HPV vaccine, cascades of inflammation, initiated by the GARDASIL HPV Vaccine, contributed to/resulted in, infected leukocytes migrating into her joints, which resulted in Diffuse Pigmented Synovitis, an inflammatory condition which infects and corrupts joints. Metals and other toxins may enter the brain and Central Nervous System when overly sensitized mast cells, typically the result of one or more (concomitant) vaccine adjuvants, triggers the release of high levels of histamine, which dilates blood vessels (causing fainting, lightheadedness, and low blood pressure), and permeates the Blood Brain Barrier. This was observed by Phillips et al, 2010, who determined that many of the girls who "fainted" shortly after receiving the Gardasil HPV vaccine, appeared to suffer a "toxic shock" type of reaction to a component in the HPV vaccine. One medical student, who is now a doctor, reported that her blood pressure had plummeted to 50/32, possibly indicating a massive histamine release from mast-cells, possibly triggered by sensitized/overabundant eosinophils (Piliponski et al: Int Arch Allergy Immunol 1999;118:202-203 (DOI: 10.1159/000024067).
A significant number of the families interviewed stated that their child had previously been exposed to areas where a mold or fungus existed, and a significant subset of these children had suffered a (serious) reaction at the time of initial exposure. If a histamine-producing allergic response is present, the histamine-dilated blood-brain-barrier may pose an elevated risk of infection of the brain and central nervous system by blood borne pathogens.
(note: Large amounts of histamine are also released during teething, making this a potentially dangerous time to vaccinate an infant or toddler, due to the unpredictable permeation of the blood brain barrier.)
Aluminum Hydroxide from vaccines and other sources, has an affinity for attaching to, and degenerating or destroying neurons, especially the motor neurons in the spinal chord (PMID: 19740540), (PMID: 17114826), (PMID: 10335362). If inflammation is not immediately brought under control, additional mast cells may become sensitized and proliferate (producing Mastocytosis-like symptoms), resulting in (increased) allergies, asthma, and food allergies, which may result in additional cascades of inflammation when these newly sensitized mast cells are triggered.
Cytokines (hormones) that normally control inflammation, such as Interleukin 10, may fail to do their job. Interleukin-10, an anti-inflammatory cytokine that helps keep inflammation in check, may become "viral Interleukin-10 (vIL-10)" when infected by something as common as the Acne Vulgaris bacteria. This means that a person with Acne may not sufficiently limit inflammation and swelling by way of Interleukin 10.
This study unexpectedly revealed that a significant number of infants, children, and adults, showed symptoms consistent with infectious vector-borne pathogens, and many were ultimately diagnosed with Bartonella and related co-infections, and had been bitten by fleas, spiders, or other vector borne (biting) insects. Family pets, especially ferule (wild) cats, are known reservoirs for Bartonella and other Lyme-related infections. These infections may appear dormant after initial exposure, but become activate when the subject's immune system suffers a significant inflammatory event, such as a vaccination. In one documented case, a neighbor of a man who fed ferule cats, was bitten by fleas from these cats, who wandered into her yard. The woman suffered for years from debilitating and undiagnosed Bartonella, FL1953, and other Lyme Disease related co-infections.
Recent research indicates that Borrelia burgdorferi, a.k.a. Lyme Disease, is becoming more common, and can remain undiagnosed for years, and appears to be approaching epidemic proportions (PMID: 16704808), (PMID: 18641487), (PMID: 836338). In 2006, 10,000 cases of Lyme Disease were reported, and 30,000 were reported in 2008. Phillips et al. estimate that less than 1% of the actual cases of Lyme Disease are actually reported, citing the failure of prominent institutions like Children's Hospital of Philadelphia, Johns Hopkins, and others, to properly diagnose Lyme Patients. Instead, these patients have been wrongfully dismissed with "CONVERSOIN DISORDER." Only a rare group of doctors, commonly known as Lyme Literate Medical Doctors (LLMD), have kept their education up-to-date, and are capable of diagnosing and treating Chronic Lyme disease. (note: Due to financial interests, insurance companies, and politics, mainstream medicine wrongfully sells expensive and sometimes inappropriate drugs, in an effort to treat chronic Lyme Disease symptoms, and manage pain. *Required reading: http://scientificliving.net/2010/07/the-lyme-epidemic-idsa-caught-with-conflicts-of-interest/). Phillips et al have found that the Gardasil HPV vaccine is notorious for activating/re-activating dormant Lyme Disease and/or Lyme Disease Co-Infections, such as Bartonella, FL1953, Babesia, Mycoplasma, etc., in addition to enteroviruses, such as Epstein Barr. A past history of Mononucleosis (Glandular Disease) has proven to be a predictor of a severe adverse reaction to a vaccination. Many medical professionals fail to keep up to date with environmental issues that can seriously affect their patients, such as the Giant African snails currently invading South Florida (early 2012), which carry "Lungworm" that can cause meningitis (swelling of the brain).
A protozoa called FL1953, is the 'new kid on the block, and can be reactivated by trauma to the body, after years of lying dormant. Preliminary data suggests that FL1953 is very common, and appears to be strongly associated with Multiple Sclerosis. Pathogens such as Epstein Barr Virus and FL1953, formally known as Protomyxoa Rheumatica, may go from dormant to virulent during periods of chronic inflammation. These pathogens "hibernate" in persister cells and biofilms. Like the textbook pathology of 70% of the cases of Viral Encephalitis, as described in the MERCK MANUAL, these and other pathogens, like Lyme Disease and the infections that are commonly found with it, may become virulent and appear years after the initial exposure, and can cause Chronic Fatigue Syndrome, mood swings, joint pain, severe headaches, sensitivity to light and sound, blurred vision, seizures, plus many more symptoms. Inflammation incubates these dormant pathogens, commonly through TH17 inflammatory cytokines. Many doctors often tell the patient that it's all in their head, especially if the patient is a young girl, and dismiss symptoms as "hormone related." Lyme Disease spreads through the body primarily by infected leukocytes, and secondarily, by blood and other body fluids, and may infect other humans through saliva and breast milk (PMID: 9119462), (full study: Am. Journal of Pathology), (Infection and Immunity: Apr. 1997, p. 1273–1285). Human environmental toxin sensitivities to "FDA Approved" chemicals are also proving to be deadly, especially in the immunocompromised. An example of this was the sudden increase in death rates among Cleveland Clinic's dialysis patients, when a Miami area municipality suddenly switched to a bromine water purifying agent. Bromine attaches to iodine receptors, and may further inhibit thyroid function. Common pathogens that hijack cytokines include, but are not limited to: infectious vector-borne bacterium, such as the seizure-causing Bartonella; Borrelia Burgdorferi (Lyme Disease); Babesia, which feeds on the iron in Heme Cells (red blood cells), thus causing "air hunger," and eats the iron out of joint cartilage, leaving iron oxide deposits behind; plus the recently identified FL1953 Protozoan, a.k.a. Protomyxoa Rheumatica, which preliminary data suggests is associated with Multiple Sclerosis and Chronic Fatigue Syndrome (CFS).
Deaths resulting from the near epidemic of Babesia and other infectious pathogens from blood transfusions and blood products, including vaccines, is just beginning to be uncovered, pointing to the extent of the contamination of the American blood supply and the drugs made from human tissue and blood products (PMID: 21893613), (PMID: 16507014). Three common initiators of inflammation are: 1) accidental or deliberate physical trauma to the body; 2) invasive medical procedures; and 3) vaccinations. Of these three, vaccinations result in the greatest number of adverse and life-threatening events, and virtually all begin with the inflammation producing vaccine chemical additives called adjuvants. Adjuvants typically force the antibody producing "TH2 immune system" to be "turned on" for unnaturally long periods. The activation of microbial products, such as found in PREVNAR and other vaccines, occurs through the interaction of Toll Like Receptors (TLRs), which results in the signaling of pathways, such as NF kappa-B, which promote the release of pro-inflammatory cytokines. Without advanced immune-response testing, such as a minimum would include C3a and C4a as part of a Wellness Visit, which would cut into the profits of doctors belonging to the 'American Academy of Pediatrics' labor union, the potentially uncontrolled amount of inflammation, initiated by a vaccine, can be potentially life threatening for a small, but growing, subset of the population.
Uncontrolled inflammatory immune response 9 days post Hep B vaccination, just hours before death.
Note signs of vaccine-induced SJS on infant's face and hands.
Newly published research from 2012 reveals that the Hepatitis B vaccine causes the inflammation and death (apoptosis) of cell Mitochondria (PMID: 22249285).
The amount of inflammation varies between individual patients receiving vaccines, and may can become potentially more dangerous and life threatening when multiple vaccines are administered concomitantly (given within a short period of time). Each individual's unique immune response is never exactly the same for any two given times, and constantly varies with the unique state of health and varying pathogen load of the patient from hour to hour. For this reason, vaccine manufacturers, such as MERCK PHARMACEUTALS, have quietly excluded people who have allergies, or who have previously received any other vaccine(s) within a four week period. These people are NOT allowed to participate in clinical trials of their vaccines, including the company's own Gardasil HPV Vaccine (MERCK: Gardasil "ClinicalTrials.gov" (Trial #NCT01096134) - see "EXCLUSION CRITERIA" for the "MOTHER-DAUGHTER INITIAVE"). Another Clinical Trial with heavy EXCLUSION CRITERIA is for the GlaxoSmithKline(GSK) CERVARIX HPV Vaccine: (GSK: CERVARIX "ClinicalTrials.gov" (Trial #NCT00492544) - see "EXCLUSION CRITERIA" for the "Immunogenicity and Safety of GSK Biologicals' HPV Vaccine 580299 in Healthy Japanese Females 10-15 Years of Age"). Vaccine manufacturers acknowledge that their products can have adverse effects in a relatively large subset of the population, and carefully exclude these individuals during Clinical Trials, but doctors with financial interests, such as Paul Offit, or the labor group: American Academy of Pediatrics, publicly and wrongfully tell public officials and parents and children with allergies that vaccines are safe for them. In the case of Paul Offit MD, negligently states that an infant can be given 10,000 vaccines at the same time, while vaccine manufacturer MERCK and GlaxoSmithKline will exclude a child from their clinical trials if they receive even one additional vaccine. Many misguided pro-vaccine groups dictate the need for "antibodies" to be present for the body to fight a pathogen, while failing to acknowledge and completely ignoring the existence of the Natural Killer (NK) Cells of the innate immune system, the body's first line of defense. NK Cells are pre-programmed to fight viruses, bacteria, vector-borne pathogens, and even cancer.
The adjuvant in vaccines, especially aluminum hydroxide, is very efficient at activating the immune system, but the resulting inflammatory hormones, such as Interleukin-18 and Interleukin-1β (one beta), are now increasingly being documented for causing damage to the gut, brain, airways and lungs. Peer reviewed and published literature shows that inflammatory Interleukin-18 and Interleukin-1β (one beta) produce inflammation in the gut (PMID: 17404311) & (PMC1373865), inflammation in the brain (PMID: 11898392) & (PMID: 21184660), and inflammation in the airways and lungs. Interleukin-18 and Interleukin-1β have been documented to be associated with asthma and Chronic Obstructive Pulmonary Disease (COPD) (PMID: 15668323) & (PMID: 10471611). Under most circumstances, the inflammation is self-limiting. In a growing subset of people, this self-limiting does not occur, especially when excessive inflammation is generated from the administration of multiple (concomitant) doses of vaccines. The immune system may then form biofilms in an attempt to isolate foreign pathogens. According to research conducted by Washio and Morikawa of Hokkaido University in Japan, these biofilms can produce vitamin K2 in the form of Menaquinone (MK-7), at concentrations of 0.5 micrograms per milliliter in a 24 hour period. Menaquinone is a clotting co-factor, and can result in blood clots, or exacerbate existing clotting disorders, and may contribute to life-threatening adverse effects, such as SIDS. Mycotoxins from the yeast or fungus medium, used to grow viruses and bacteria for vaccines, may cause a massive histamine release (allergic response) when injected into a sensitized person, especially those people with elevated eosinophils. This may cause a sudden dilation of blood vessels, which may result in syncope (fainting) as blood pressure suddenly plummets [PHILLIPS et al, 2010]. This has resulted in documented BPs as low as 50/32 in one medical student, who "fainted" after returning to class, within minutes of receiving the Gardasil HPV vaccine. Newly published research from 2012 reveals that the Hepatitis B vaccine causes the inflammation and death (apoptosis) of cell Mitochondria (PMID: 22249285). Mitochondria are present in every cell of the body, and compromised mitochondria inhibit the immune system and metabolic functions. Five concomitant vaccines, containing both aluminum and mercury adjuvants (different metals), may result in a synergistic increase in inflammation that is many times greater than the expected 500% (PMID: 731728). The primary Blood Brain Barrier consists of tightly packed endothelial cells in the walls of capillaries in the brain, while Glial cells make up the brain's secondary Blood Brain Barrier, and surround the capillaries. Glial cells are macrophages that outnumber neurons 10 to 1, and help regulate nutrients flowing to the brain by active transport. When Glial cells become inflamed, a proportionate number of oligodendrocytes also become inflamed. Oligodendrocytes are the macrophage cells in the brain that make the myelin sheath that surrounds nerves. Failure of this protective myelin sheath around nerves results in degenerative nerve diseases, such as Multiple Sclerosis (MS). The continued ingestion of metals, including the use of aluminum based anti-perspirants, antacids, or foods containing aluminum, including baked goods using an aluminum baking powder, will now help to sustain inflammation, and some aluminum (al[+3]) may pass through the inflamed and permeated blood brain barrier, and contribute to a further debilitating neurodegenerative cascade of events. GABA supplementation is cautioned in an individual with a blood brain barrier disorder, as it may severely disrupt cognitive functions. To feed inflammation, the body needs additional calcium, magnesium, etc., and may break apart mineral-rich biofilms, which the immune system uses to quarantine pothogens. The pathogens that were formerly encapsulated in antibiotic resistant biofilms, including vector-borne pathogens and co-infections transmitted by mosquitoes, fleas, spiders, ticks, human or animal saliva, etc., are now exposed, and may become virulent, resulting in a further debilitating cascade of inflammatory events. In 2001, a pandemic of Lyme Disease was detected in 90% of the 100 New Jersey horses tested: "Antibody titers to B. burgdorferi were detected in 90 (90%) serum samples by ELISA, with 15 (17%) of the positive horses having reciprocal antibody titers of 10,240 or greater" HAGSTOZ et al, 2001: Bulletin of the New Jersey Academy of Science, Fall 2001, vol. 46, issue 2. In study, all female children who were tested in a group who reported severe adverse reactions to the Gardasil HPV vaccine, and who were typically diagnosed with "Conversion Disorder," actually had NK-CD57 counts ranging between 8 and 51. Further testing revealed that they were infected with varying degrees of Bb, Bartonella, Babesia, FL1953 (Fry Labs: PCR for FL1953), plus other pathogens and Lyme-related co-infections (PHILLIPS et al, 2011). A fully intact Blood Brain Barrier passes Spirochetes, such as Borrelia, commonly referred to as Lyme Disease. Viruses and enteroviruses, such as Epstein Barr Virus (EBV), CMV, XMRV, etc., may also be reactivated. Fast growing Interleukin-17 cytokines, from the recently discovered TH-17 immune response, have now been documented as being capable of acting as incubators for viruses and pathogens, such as Epstein Barr, which may help explain the increase of autoimmune symptoms during flares of inflammation. Attenuated viruses from vaccines may also multiply under these circumstances, as may be evidenced by the 83% increase of antibodies to the strain of measles found in the MMR vaccine in the serum of autistic children. These antibodies are not found in normal children, nor in non-autistic siblings of autistic children (PMID: 12849883). Bartonella henselae, commonly transmitted by mosquitoes, fleas, and other arthropods, may be reactivated, and may infect and inflame the optic nerve and liver, cause endocarditis, result in acute pain in areas of infection, cause streaks and rashes after showers, plus much more, including papules or nodules on the skin, and tumor-like masses, known as Bacillary angiomatosis (BA). Bacillary angiomatosis may also affect the brain, bone, bone marrow, lymph nodes, GI tract, respiratory tract, spleen, and liver. Pathogen-infected leukocytes may now migrate into joints, and in the documented case of an eleven year old Canadian girl, resulted in Diffuse Pigmented Synovitis. Bartonella, FL1953 (Protozoa Rheumatica), Borrelia burgdorferi, and other vector-borne pathogens have been observed in a significant number of the girls suffering adverse effects from the Gardasil HPV vaccine (Phillips et al, 2010). According to recent peer reviewed and published data, the arrogance, ignorance, negligence, and failure of the AMA, AAP, AHA, and many doctors to recognize, acknowledge, diagnose, and treat the epidemic of Lyme Disease, is just now beginning to be addressed (PMID: 20508824), along with associated co-infections, such as Bartonella and Babesia, from infected vector-borne sources and contaminated blood transfusions in the immunocompromised and elderly (CDC: Journal of Emerging Infectious Disease, Volume 18, Number 1—January 2012). Infections, such as Babesia, may last from months to years (PMID: 9664092). The multitude of antibiotics wrongfully prescribed to these patients appears to be contributing to making the growing incidence of Lyme Disease and its co-infections, antibiotic resistant (PMC: 2876246) (PMID: 18447934) (Reuters) (FOX NEWS). Bartonella has recently been found in lice from the homeless in San Francisco (PMC: PMC2727331). Persister cells, a form of antibiotic resistant dormant pathogen(s) (PMID: 20528688), may also be signaled to become virulent, and appear to be more readily reactivated in the presence of metals such as Pb(2+) and Al(3+), and also by metals typically found in mineral supplements such as Co(2+), Ni(2+), Cu(2+), and Zn(2+). Because of peer reviewed and published abstracts, we find that the aluminum hydroxide adjuvant in vaccines, Al(3+), allows biofilms and persister cells to become more accessible to re-infect the human body (PMID: 15946294), which may help explain susceptibility to (rare) chronic infectious diseases, such as Nontuberculous Mycobacteria (NTM), simply by inhaling mist from a shower head while washing (PMID: 1120248), (PMID: 21728159), (PMID: 19824053). The aluminum hydroxide adjuvant in a vaccine may actually increase the risk of infection or disease in a subset of the population harboring biofilms or persister cells (Phillips et al, 2010). Latent or dormant pathogens, in the form or persister cells/biofilms, may be reactivated or made virulent by a vaccination or other immune system trauma. This reactivation may result in a serious or life threatening reaction. Although the technology exists, infants, children, and adults are not tested for any of these potentially life threatening pathogens or deadly inflammatory cytokine responses (deficient T-Regulator cells that can result in uncontrolled inflammation), during "wellness visits," or prior to vaccinations or invasive surgery. It is medical negligence to assume that every child's immune systems responds safely and equally to vaccination(s). While lab animals used for vaccine testing are in *perfect* health and fed *perfect* diets, infants and children are blindly vaccinated, while pediatricians [negligently] fail to acknowledge, test for, or identify the unique and sometimes potentially deadly pathogen loads and polymorphisms of each patient. We hypothesize that human screening, prior to vaccination, would greatly reduce or virtually eliminate vaccine induced autism. Upon detection, immediate treatment of vector-borne pathogens would significantly reduce present and future "autoimmune disease," and reduce the billions of dollars in Federal funding needed to treat these patients and their disabilities. Unfortunately, this would cut deeply into the profits of drug manufacturers and investors like Senator John McCain, Donald Rumsfeld, and others, who rely on the U.S. Population to pay virtually any price for doctors and prescription drugs, in an effort to remain pain-free and in good health. However, when vaccine manufacturers wish to prove the safety of their vaccines, they will often allow only one vaccine to be administered, and exclude people who have ANY allergies, asthma, or immune dysfunction (See MERCK clinical trial: "MOTHER-DAUGHTER INITIAVE" "Exclusion Criteria"). (Note: Doctors should recognize that when a vaccine manufacturer such as MERCK, starts excluding patients from lucrative vaccinations, to obtain good clinical trial results, it has to be based on very serious or possibly deadly inside company information, that is not being disclosed to the general public). Patients with a history of allergies, asthma, Infectious Mononucleosis, or a Vector-Borne Infection such as the FL1953 Protozean, Borrelia (Lyme Disease), Babesia, and Bartonella, present a higher risk for life threatening reactions. The risk becomes even greater if they receive one or more concomitant vaccinations, especially since VEGF from Bartonella and some other infections, can permeate the Blood Brain Barrier, and enter the brain and CNS (Phillips et al, 2010). Pathogens may also enter the brain and CNS through brain stem nerve terminations at the Root Entry Zone (Psychiatry (Edgmont). 2010 January; 7(1): 13–16.; PMCID: PMC2848459). From an autism standpoint, the worst time to vaccinate an infant is while they are teething, because the Blood Brain Barrier that protects the brain and CNS is permeated (opened), due to the elevated histamine produced by teething. Histamine from mast cells in a child with allergies also opens the Blood Brain Barrier. Compared to a 140 pound woman in good health, with no allergies, and a properly functioning Blood Brain Barrier, levels of inflammation-producing vaccine adjuvants are 2,000% higher in a 7 pound infant. An infant girl receives greater neuroprotection because of estrogen, while mercury accumulates in a male child, due to testosterone binding (PMID: 15780490), as can be verified by the higher incidence of autism and related disorders in vaccinated male children. An infant/child/adult who was healthy, may now encounter (flares of) debilitating and sometimes life-threatening symptoms or events. In Phase II (chronic phase), inflammation is typically diminished but sustained, with sometimes intermittent acute flares of symptoms. Pathogen activity may increase. Food sensitivities/allergies may increase as food proteins contact antibody generating immune cells in the lining of an inflamed gut, resulting in new food allergies, which leads to malabsorption, resulting in a new cascade of debilitating events due to decreased nutrients and impaired enzyme production, especially Nrf2 Disruption. Nrf2 is a redox-sensitive transcription factor that upregulates a battery of antioxidative genes and cytoprotective enzymes (PMID: 19023427). Due to elevated LPS stimulated IL-4 and decreased Nrf2, resulting in oxLDL, it is easy to predict CD36 macrophage fusion, which could result in giant cell formation, such as those found in granulomatous infections, such as Sarcoidosis. Serrapeptase has been found to block this formation (J Cell Sci. 2009 February 15; 122(4): 453–459 ). Decreased nutrient absorption results in less Hyaluronic Acid (HA) production, and if Lyme Disease is present, may result in accelerated impairment of connective tissue, ball and socket joints, neuron functioning in the brain and CNS, and a higher risk of vision problems and macular degeneration, due to the attraction of the Lyme Spirochete to these areas of the body that are rich in Hyaluronic Acid. The practitioner must be proficient in using oral Hyaluronic Acid in luring these Spirochetes away from critical body systems and into the gut, where they can be mitigated by the constant administration of low levels of antibiotics, or something as simple as 500-700 milligrams of fresh or freeze dried garlic. If a common (seizure causing) Bartonella bacterial infection has also been reactivated, CD44 may likely be disrupted (upregulated), and the binding properties of Hyaluronan may be impaired, which may result in disruption of neuronal development, cellular regeneration, connective tissue and endothelial cell homeostasis, wound repair, and may contribute to Autism Spectrum Disorder (PHILLIPS et al, 2011). 1,200 genes (mRNA) of endothelial cells were studied after being exposed to a Bartonella infection, and 706 genes and their genetic responses (chemical secretions, etc.) and manifested physical symptoms, were found to be altered by a Bartonella henselae infection (PMID: 16113825), (full transcript: **MUST READING**). While 304 of these genes were found to modify a formerly healthy Innate Immune System, this family of infectious pathogens can and have remained undetected by the majority of 'medical professionals' and institutions, including the prestigious Children's Hospital of Pennsylvania (CHOP), home of Dr. Paul Offit, and Johns Hopkins, home of Neurologist and vaccine developer, Avindra Nath. It is common for these 'medical professionals' to inform their patients that their possible life-threatening conditions are nothing more than a manifestation of their mind, and incompetently and wrongfully diagnose their seriously ill patient with "Conversion Disorder." If multiple infectious pathogens are active (very common), symptoms may appear even more skewed and bizarre. This has been seen in a significant number of patients who experienced adverse effects to the Gardasil HPV vaccine (PHILLIPS et al, 2011). We hypothesize that with the quick onset of Global Warming, the arthropods that spread these pathogens will rapidly increase, and these infections may become even more common and virulent. The addition of, or the regular ingestion of freshly prepared garlic to the diet, may also help reduce Spirochetes and other pathogens. Caution must be used by the practitioner to administer small doses when starting this regimen, to keep the immune response under control, and avoid an uncontrolled systemic inflammatory response in chronically infected individuals as determined by elevated C3a, C4a, elevated LPS stimulated cytokines, or other inflammatory or autoimmune marker, especially low NK-CD57 counts. Additionally, Hyaluronic Acid may stimulate metastasis, so foods that promote angiogenesis are highly suggest in the diet (PMID: 12750291). As you can see through scientific and peer reviewed research, these cascades of debilitating events are predictable, have simple cause and effect mechanisms, can be potently deadly if left untreated, and can be even more deadly in the hands of an uninformed physician. Allergens may stimulate newly sensitized or overly abundant mast cells, and cause them to overproduce histamine (Histadelia), which dilates blood vessels, and can produce MANY other symptoms, including Postural Orthostatic Tachycardia Syndrome (POTS). Because of inflammation, elevated amounts of cortisol are also being released, resulting in short-term memory loss, irritability, fatigue, and much more. The body may become more acidic. As ph decreases, synapse firing is altered, especially in the presence of a Glutathione S-Transferase Deficiency, which can impair mitochondrial activity, due to changes in electrolyte characteristics of body fluids, caused by elevated levels of contaminants and toxins, which affects the electrical charge of the membrane of every cell in the body. A zinc deficiency may contribute to, or exacerbate, a glutathione S-Transferase Deficiency (Journal of Nutrition. 2000;130:38-44). When Glutathione S-Transferase is deficient, CD36 antioxidant functioning/scavanging/binding may be severely impaired, which may lead to toxin disorders from failure to properly dispose of apoptic cells, tissue disorders, and clotting and other pulmonary disorders/events such as excessive LDL and related issues (PMID: 9857015), (PMID: 19023427). Typical inflammatory markers may appear somewhat lab-normal on a Comprehensive Cytokine Panel, except for LPS stimulated cytokines, which may appear 1/4th lab normal, but cytokine base counts will usually appear somewhat normal. Multiple vector borne pathogens have been observed in these in the 2010-2011 study of girls severely affected by the Gardasil HPV vaccine. Bartonella, HHV6, and several others, are suspect if seizures are present. FL1953 is suspect if connective tissue disorders, joint pain, air hunger, or fatigue are present, with or without a positive Western Blot, especially when family pets or livestock are present. Families with a history of Epstein Barr, Mononucleosis, arthritis, asthma, allergies, or a Glutathione S-Transferase Deficiency (GSTM1, GSTP1, GSTT1, etc. polymorphism) are at greatest risk. Through extended interviews with patients, a high arch on the foot, as seen in Charcot Marie Tooth Disease, is being observed in a significant number of affected patients (Phillips et al, 2010), and appears to be an additional risk factor. After the patient is placed on a low-fat, restricted carbohydrate diet, the administration of Low Dose Naltrexone has proven helpful, if started at a safer level of 0.5 milligrams if good liver and kidney function is observed. In cases where inhibited liver or kidney function present, the initial dose must be further reduced to 0.1 milligrams per day in order to reduce/eliminate potential headache or possible thoughts of suicide. (Phillips et al, 2010). If LDN is started at 0.1 milligrams, it should be increased by 50% each two week period, until a 3.0 to 3.5 milligram per day maintenance dose is achieved (PMID: 20965606). If LDN is started at 0.5 milligrams for a patient with AST & ALT within normal range, the dosage may be increased to 1.0 milligram after two weeks, and increased by 1.0 milligrams each week if no adverse effects are observed, until a maintenance dose of 3.0 to 3.5 milligrams per day is achieved. Naltrexone is normally administered at 3.2 milligrams per 100 pounds of body weight, with 3.0 to 3.5 milligrams being optimal for most teens and pre-teens, and should never exceed 4.0 to 4.5 milligrams per day. Low Dose Naltrexone cleared acne within one month on an 18 yr old fem patient, and allowed her to return to dancing. Low Dose Naltrexone has been found to help reduce glial cell inflammation in the brain, which helps restore a permeated blood brain barrier, and return the immune system to homeostasis in cases where an overproduction of T-lymphocytes has resulted in the immune system attacking self (autoimmune disease). Low Dose Naltrexone appears to have the greatest affect on patients with chemical and food sensitivities, typically the result of vaccination-induced inflammation, and helps normalize elevated mast-cell sensitivity [PHILLIPS et al, 2010].